Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in pregnant rat model: An analysis on the effectiveness of administration methods to induce high blood pressure in pregnancy

Hypertensive disorders of pregnancy (HDP) contribute to high percentage for both maternal and foetal morbidity mortality associate with long term complications. A history having HDP is a known risk factor women's cardiovascular disease later in their life even though blood pressure normalizes during postpartum period. L-NAME drug that has been used pharmacologically induce hypertension by inhibition nitric oxide synthase (NOS). In the previous study, there are various administration methods pregnant rat model using L-NAME, but they produced inconsistent outcomes.